Synthesis of cholic acid based calixpyrroles and porphyrins

New cholic acid based calix[4]pyrroles and porphyrins were prepared and their properties were studied. It was confirmed by spectral measurements that the superassembly of 5,15-bis(3α,7α,12α-trihydroxy-5β-cholan-24-yl)-10,20-diphenylporphyrin, the best candidate for this study from the conjugates prepared, may be influenced not only by the solvent mixture composition (polar/non-polar component ratio) but by time as well.

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► Superassembly of porphyrin may be promoted by solvent mixture composition.
► Superassembly of porphyrin is dependent on time.
► Microwave synthesis was used to achieve better results in several synthetic steps.
► C-3 Spiroannulated oligopyrrole macrocycle was successfully synthesized.
► Synthesis of similar compound with connection at C-7 was not successful.