Synthesis of 7,8α-dihydro-14α-deoxyecdysteroids

A Pd-C-catalyzed hydrogenation in methanol and in the presence of sodium methylate is a simple, convenient and high yielding reduction method to convert the 7,14-dien-6-one ecdysteroids to their corresponding 7,8α-dihydro-14α-deoxyecdysteroids.

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► A Pd-C-catalyzed hydrogenation in the presence MeONa is a simple, convenient and high yield reduction method to convert the 7,14-dien-6-one ecdysteroids into 7,8α-dihydro-14α-deoxyecdysteroids.
► We have developed a selective procedure for the reduction of the double bonds of steroid skeleton and side chain of ecdysteroids via catalytic hydrogenation in methanol in the presence of sodium methoxide.
► The molecules structure of the obtained compounds was unambiguously proved by a single X-ray diffraction study.