کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2028191 | 1070401 | 2012 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Estradiol receptors in breast cancer cells: Associated co-factors as targets for new therapeutic approaches Estradiol receptors in breast cancer cells: Associated co-factors as targets for new therapeutic approaches](/preview/png/2028191.png)
Estrogen receptors α (ERα) and β (ERβ) are nuclear receptors which transduce estradiol (E2) response in many tissues including the mammary gland and breast cancers (BC). They activate or inhibit specific genes involved in cell cycle progression and cell survival through multiple enzyme activities leading to malignant transformation. Hormone therapy (antiestrogens (AEs) and aromatase inhibitors (AIs) have been widely used to block the mitogenic action of E2 in patients with ER-positive BC. ERs act in concert with numerous other proteins outside and inside the nucleus where co-activators such as histone modifying enzymes help reaching optimum gene activation. Moreover, E2-mediated gene regulation can occur through ERs located at the plasma membrane or G protein-coupled estrogen receptor (GPER), triggering protein kinase signaling cascades. Classical AEs as well as AIs are inefficient to block the cascades of events emanating from the membrane and from E2 binding to GPER, leading patients to escape anti-hormone treatments and hormone therapy resistance. Many pathways are involved in resistance, mostly resulting from over-expression of growth factor membrane receptors, in particular the HER2/ErbB2 which can be inhibited by specific antibodies or tyrosine kinases inhibitors. Together with the Hsp90 molecular chaperone machinery, a complex interplay between ERs, co-activators, co-repressors and growth factor-activated membrane pathways represents potent targets which warrant to be manipulated alone and in combination to designing novel therapies. The discovery of new potential targets arising from micro array studies gives the opportunity to activate or inhibit different new ER-modulating effectors for innovative therapeutic interventions.
► I review the current drugs used in breast cancer hormone therapy.
► The different localization of estradiol receptors (ERs) are described.
► The interplays between growth factors and ER signaling are examined.
► Relevant targetable ER-associated cofactors with ER-modifying functions are detailed.
► New small chemical molecules and gene manipulating intervention means are examined.
Journal: Steroids - Volume 77, Issue 12, October 2012, Pages 1249–1261