کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028192 | 1070401 | 2012 | 5 صفحه PDF | دانلود رایگان |
An increasing amount of evidence points at important roles for estrogen receptors in prostate carcinogenesis and progression. Of the two estrogen receptors, estrogen receptor β is the most prominent within the prostate gland. Although there is much yet to be known, the findings from the discovery of the receptor in 1996 until now point at a role of the receptor in maintaining differentiation and reducing cellular proliferation in the prostate. Moreover, estrogen receptor β is the main target for phytoestrogens, perhaps at least partially explaining the difference in incidence of prostate cancer in the Western world compared to Asia where the intake of soy-based, phytoestrogen-rich food is higher. The tumor suppressive capability of estrogen receptor β makes it a promising drug target for the treatment and prevention of prostate cancer. This review will focus on different aspects of estrogen receptor signaling and prostate cancer.
► Estrogen receptor beta is the dominating estrogen receptor within the prostate.
► Estrogen receptor beta is an important regulator of proliferation and differentiation in the prostate.
► Phytoestrogens mediate their effects through estrogen receptor beta in the prostate.
► Estrogen receptor beta could be a selective target for a subtype specific therapy in prostate cancer.
Journal: Steroids - Volume 77, Issue 12, October 2012, Pages 1262–1266