Transetherification-mediated E-ring opening and stereoselective “Red-Ox” modification of furostan

We have developed a novel E-ring opening method for furostan, and applied it to prepare D-ring modified steroids, which can be used to synthesize cephalostatin analogs.

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► Development of a novel E-ring opening of furostan.
► Facile introduction of D-ring diene via transetherification.
► Stereoselective “Red-Ox” modification of steroidal D-ring diene.