Tissue physiology and pathology of aromatase

Aromatase is expressed in multiple tissues, indicating a crucial role for locally produced oestrogens in the differentiation, regulation and normal function of several organs and processes. This review is an overview of the role of aromatase in different tissues under normal physiological conditions and its contribution to the development of some oestrogen-related pathologies.

► Aromatase is expressed in multiple tissues.
► Tissue-specific expression of aromatase controls local oestrogen actions.
► Locally produced oestrogens regulate normal and anomalous processes.