کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028268 1542731 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men
چکیده انگلیسی

ObjectiveLower levels of anabolic hormones in older age are well documented. Several studies suggested that low insulin-like growth factor I (IGF-I) or testosterone levels were related to increased mortality. The aim of the present study was to investigate the combined influence of low IGF-I and low testosterone on all-cause mortality in men.Methods and resultsFrom two German prospective cohort studies, the DETECT study and SHIP, 3942 men were available for analyses. During 21,838 person-years of follow-up, 8.4% (n = 330) of men died. Cox model analyses with age as timescale and adjusted for potential confounders revealed that men with levels below the 10th percentile of at least one hormone [hazard ratio (HR) 1.38 (95% confidence-interval (CI) 1.06–1.78), p = 0.02] and two hormones [HR 2.88 (95% CI 1.32–6.29), p < 0.01] showed a higher risk of all-cause mortality compared to men with non-low hormones. The associations became non-significant by using the 20th percentile as cut-off showing that the specificity increased with lower cut-offs for decreased hormone levels. The inclusion of both IGF-I and total testosterone in a mortality prediction model with common risk factors resulted in a significant integrated discrimination improvement of 0.5% (95% CI 0.3–0.7%, p = 0.03).ConclusionsOur results prove that multiple anabolic deficiencies have a higher impact on mortality than a single anabolic deficiency and suggest that assessment of more than one anabolic hormone as a biomarker improve the prediction of all-cause mortality.


► The impact of IGF-I and testosterone on mortality were investigated in men.
► Two study population consisting 3942 men were used.
► Men with low levels for both hormones showed a higher risk of all-cause mortality.
► Multiple anabolic deficiencies have a higher impact on mortality than single anabolic deficiency.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issues 1–2, January 2012, Pages 52–58
نویسندگان
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