کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028292 | 1070408 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A diastereoselective synthesis of 7α-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel and efficient method of stereoselectively introducing α-nitromethyl group to C-7 position of 11α-hydroxyl canrenone 4 was described. In addition, this method was successfully applied in a total synthesis of Eplerenone 8. The route was characteristic of simple operation, moderate reaction conditions with 5 steps and 55% total yield, at the same time, without any expensive or toxic reagent in use.
Figure optionsDownload as PowerPoint slideHighlights
► A novel and efficient method for stereoselective introduction of nitromethyl group to C-7 position of 11α-hydroxyl canrenone 4.
► A novel total synthesis of eplerenone with five steps and 55% total yield.
► 7α-nitromethyl steroid derivative was afforded for the first time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issue 11, September 2012, Pages 1086–1091
Journal: Steroids - Volume 77, Issue 11, September 2012, Pages 1086–1091
نویسندگان
Bin Zhang, Hongli Chen, Huanyu Tang, Huijin Feng, Yuanchao Li,