کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028301 | 1070408 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Design and studies of novel polyoxysterol-based porphyrin conjugates Design and studies of novel polyoxysterol-based porphyrin conjugates](/preview/png/2028301.png)
New types of steroid-porphyrin conjugates derived from 20-hydroxyecdysone (20E) and 24-epibrassinolide (EBl) were synthesized. An exceptional regioselectivity in the reaction of both steroids with porphyrin boronic acids was found to give side-chain-conjugated boronic esters as sole products. UV–Vis-, fluorescence and NMR spectroscopy yielded similar data for all the studied compounds confirming the solvent driven supramolecular assembly with formation of J-aggregates. CD measurements of water diluted solutions showed a clear difference between 20E and EBl conjugates. The latter showed a strong supramolecular chirality, whereas 20E J-aggregates did not.
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► Steroid–porphyrin conjugates have been synthesized.
► Side-chain-conjugated boronic esters were formed as sole products.
► Spectral studies confirmed the solvent driven formation of J-aggregates.
► 24-Epibrassinolide conjugates showed a strong supramolecular chirality.
Journal: Steroids - Volume 77, Issue 11, September 2012, Pages 1169–1175