کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028378 1542735 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental hormones: Multiple pathways for response may lead to multiple disease outcomes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Environmental hormones: Multiple pathways for response may lead to multiple disease outcomes
چکیده انگلیسی

Compounds that mimic vertebrate hormone responses are found throughout the environment, and some are implicated in endocrine disruption. Endocrine disruption has been found in humans, wildlife, and even in the partnership of plants and root symbionts. Most endocrine disruption occurs in estrogenic systems. Estrogens, like other steroid hormones, binds a transcription factor known as a nuclear receptor to regulate gene transcription. Recent research has shown that there are other signaling mechanisms for steroid hormones that involve kinase pathways and G protein-coupled receptors. Mounting evidence suggests estrogen mimics can also act by these pathways which work outside the nucleus. Differential expression of these pathways across cell types, and differential affinity for these pathways by diverse compounds may explain some patterns of endocrine disruption and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 75, Issues 8–9, August–September 2010, Pages 520–523
نویسندگان
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