کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028452 1070419 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited
چکیده انگلیسی

The interplay between mineralocorticoids (MCs) and glucocorticoids (GCs) in sodium transporting epithelia is complex and only partially understood. In seminal papers published in the years soon after the discovery of aldosterone, various investigators experimentally observed that mineralocorticoid-induced renal sodium retention could only be reliably measured in adrenalectomized animals. Addition of endogenous GCs or their 11-dehydro metabolites blunted the antinatriuretic action of aldosterone and 11-dehydro-GCs decreased binding of aldosterone to mineralocorticoid receptors (MR). Under normal circumstances, endogenous GCs alone do not induce sodium transport in MC responsive epithelia yet these same GCs are able to activate MR and induce sodium transport if the enzyme 11β-HSD2 is inhibited. Given the physiologic concentrations of both MCs and GCs, it is likely that the local epithelial cell exposure to GCs is great enough to allow GC binding to MR despite the presence of 11β-HSD2. Thus other factors supplement the receptor selectivity role suggested for 11β-HSD2. Why GCs bind to MR under one set of conditions and produce no effect and under different sets of conditions (11β-HSD2 inhibition) elicit sodium transport remains a puzzle to be solved. What is clear is that a dual role for 11β-HSD2 is emerging; first as the putative “guardian” over the MR reducing GC binding, and second as a source for 11-dehydro-GCs, which may serve as endogenously and locally produced “spironolactone–like substances”, which may thus attenuate aldosterone-induced sodium transport.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 74, Issue 1, January 2009, Pages 1–6
نویسندگان
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