کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028500 | 1542732 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological activity of ring-A difluorinated brassinosteroids
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this paper we report the synthesis of four ring-A difluorinated analogs of brassinosteroids. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that one of these analogs elicits a bioactivity comparable to that of 28-homocastasterone, a highly active natural brassinosteroid. This finding suggests that both hydroxyls at C-2 and C-3 in active brassinosteroids are involved as hydrogen bond acceptors in their interactions with the cellular receptor.
► Ring-A difluorinated brassinosteroids analogs were synthesised for the first time.
► Fluorination at C-2 and C-3 leads to a highly active compound.
► Difluorination at C-3 yields a completely inactive analog.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 76, Issues 10–11, September–October 2011, Pages 1016–1020
Journal: Steroids - Volume 76, Issues 10–11, September–October 2011, Pages 1016–1020
نویسندگان
Sofía L. Acebedo, Fernando Alonso, Lydia R. Galagovsky, Javier A. Ramírez,