Cross-talk between aldosterone and angiotensin signaling in vascular smooth muscle cells

► Aldosterone and angiotensin II signaling pathways crosstalk in vascular smooth muscle cells. ► Some genomic effects of angiotensin II are dependent on mineralocorticoid receptor transactivation. ► Some non-genomic effects of aldosterone are dependent on angiotensin type 1 receptor (AT1R) transactivation. ► Signaling crosstalk between angiotensin II and aldosterone-stimulated pathways contributes to the vascular pathophysiological effects of the renin-angiotensin-aldosterone system.