کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028901 1070451 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of some 17β-dihydrooxazinyl steroids, as novel presumed inhibitors of 17α-hydroxylase-C17,20-lyase
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Stereoselective synthesis of some 17β-dihydrooxazinyl steroids, as novel presumed inhibitors of 17α-hydroxylase-C17,20-lyase
چکیده انگلیسی

17β-Dihydrooxazinyl steroids 5a–l and 6a–l were synthetized. The acid-catalyzed reactions of 21-azidomethyl-20-hydroxy- and 21-hydroxymethyl-20-azidosteroids with substituted aromatic aldehydes led to the formation of androst-5-en-3β-ols substituted in position 17β with dihydrooxazine residues. The inhibitory effects of these compounds on rat testicular C17,20-lyase were investigated with an in vitro radioincubation technique.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 71, Issue 9, September 2006, Pages 809–816
نویسندگان
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