Efficient microwave assisted access to chiral O-(α-protected-aminoacyl)steroids

Chiral O-(α-protected-aminoacyl)steroids 4a–f, 6a–b, 8 and 4a + 4d and O-(α-protected-dipeptidoyl)steroids 12a,b are conveniently prepared under microwave irradiation in isolated yields of 65–96%, with complete chirality retention. The reaction utilized readily available N-(Z-α-aminoacyl)benzotriazoles 2a–f and Z-dipeptidoylbenzotriazole 11, with naturally occurring steroidal alcohols 3,5,7,9.

Figure optionsDownload as PowerPoint slide