کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028951 1070456 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Four new immunomodulating steroidal glycosides from the stems of Stephanotis mucronata
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Four new immunomodulating steroidal glycosides from the stems of Stephanotis mucronata
چکیده انگلیسی

Four new C-21 steroidal glycosides, mucronatosides E (1), F (2), G (3), and H (4), were isolated from the stems of Stephanotis mucronata. Two of them had the rare aglycone with a double bond between C-6 and C-7. Their structures were elucidated on the basis of spectroscopic data and chemical evidence. These isolated compounds were assayed for their immunological activities in vitro against concanavalin A (Con A)- and lipopolysaccharide (LPS)-induced proliferation of mice splenocytes. Compounds 2 and 4 showed immunosuppressive activities in a dose-dependent manner, while compounds 1 and 3 possessed immunoenhancing activities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 71, Issue 8, August 2006, Pages 683–690
نویسندگان
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