کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2029102 | 1070480 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel 5β-hydroxyspirostan-6-ones ecdysteroid antagonists: Synthesis and biological testing
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel 5β-hydroxyspirostan-6-ones ecdysteroid antagonists: Synthesis and biological testing Novel 5β-hydroxyspirostan-6-ones ecdysteroid antagonists: Synthesis and biological testing](/preview/png/2029102.png)
چکیده انگلیسی
Eight new 5β-hydroxy-spirostan-6-ones bearing hydroxy and amino functions in the A ring, i.e., 3β-OH, 3α-OH, 2β,3β-OH, 2α,3β-OH, 3β-NH2, 2α-NH2-3β-OH, 2β-NH2-3β-OH, and 2β-OH-3β-NH2, were efficiently synthesized, and their antiecdysteroid activities were evaluated on the metamorphosis bioassay of mosquito Aedes aegypti. To our knowledge, these new steroids represent the first 5β-hydroxy-spirostanes which have been tested for antiecdysteroid activity in mosquitoes. The higher antagonistic effect was found for compounds bearing the 3β-hydroxy and 2β,3β-dihydroxy functionality, which show promise as environmental friendly insecticides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 71, Issue 1, January 2006, Pages 1–11
Journal: Steroids - Volume 71, Issue 1, January 2006, Pages 1–11
نویسندگان
Daniel G. Rivera, Fredy León, Francisco Coll, Gema P. Davison,