کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2029194 1542717 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer
چکیده انگلیسی

Androgens were at one time a therapeutic mainstay in the treatment of advanced breast cancer. Despite comparable efficacy, SERMs and aromatase inhibitors eventually became the therapies of choice due to in part to preferred side-effect profiles. Molecular characterization of breast tumors has revealed an abundance of androgen receptor expression but the choice of an appropriate androgen receptor ligand (agonist or antagonist) has been confounded by multiple conflicting reports concerning the role of the receptor in the disease. Modern clinical efforts have almost exclusively utilized antagonists. However, the recent clinical development of selective androgen receptor modulators with greatly improved side-effect profiles has renewed interest in androgen agonist therapy for advanced breast cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 90, 15 November 2014, Pages 94–100
نویسندگان
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