Steroidal sapogenins and glycosides from the fibrous roots of Polygonatum odoratum with inhibitory effect on tissue factor (TF) procoagulant activity

• Nine new compounds were isolated from the fibrous roots of Polygonatum odoratum (Mill.) Druce.
• Structure elucidation were performed based on NMR and mass spectroscopic analyses.
• The series of steroidal saponins exhibited inhibitory effect on TF procoagulant activity in THP-1 cells.

Six new spirostane glycosides (1–6), named polygodosides A–F, one new furostanol glycoside, polygodoside G (7), one new cholestane glycoside, polygodoside H (8), and one new steroidal sapogenin, polygodosin A (9), together with thirteen known compounds (10–22) were isolated from a 90% MeOH extract of the fibrous roots of Polygonatum odoratum (Mill.) Druce. The structures of new compounds were elucidated by extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. The effects on TF procoagulant activity in THP-1 cells were tested for most of the compounds.

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