کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2029215 1542721 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ergogenic and metabolic effects of oral glucocorticoid intake during repeated bouts of high-intensity exercise
ترجمه فارسی عنوان
اثرات ارگونومی و متابولیکی مصرف خوراکی گلوکوکورتیکوئیدی خوراکی در طول تمرینات شدید تمرینات شدید
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• No study has yet investigated its impact during repeated high-intensity exercise.
• Short-term GC does not improve endurance performance during this type of exercise.
• Short-term GC induces an initial increase in absolute peak force.
• Short-term GC alters DHEA but not testosterone or blood lactate concentrations.
• Short-term GC demonstrates an anti-inflammatory effect at rest and during exercise.

All systemically administered glucocorticoids (GC) are prohibited in-competition, because of the potential ergogenic effects. Although short-term GC intake has been shown to improve performance during submaximal exercise, literature on its impact during brief intense exercise appears to be very scant. The purpose of this study was to examine the ergogenic and metabolic effects of prednisone during repeated bouts of high-intensity exercise. In a double-blind randomized protocol, ten recreational male athletes followed two 1-week treatments (Cor: prednisone, 60 mg/day or Pla: placebo). At the end of each treatment, they hopped on their dominant leg for 30 s three times consecutively and then hopped until exhaustion, with intervals of 5 min of passive recovery. Blood and saliva samples were collected at rest and 3 min after each exercise bout to determine the lactate, interleukin-6, interleukin-10, TNF-alpha, DHEA and testosterone values. The absolute peak force of the dominant leg was significantly increased by Cor but only during the first 30-s hopping bout (p < 0.05), whereas time to exhaustion was not significantly changed after Cor treatment vs Pla (Pla: 119.9 ± 24.7; Cor: 123.1 ± 29.5 s). Cor intake lowered basal and end-exercise plasma interleukin-6 and saliva DHEA (p < 0.01) and increased interleukin-10 (p < 0.01), whereas no significant change was found in blood lactate and TNF-alpha or saliva testosterone between Pla and Cor. According to these data, short-term glucocorticoid intake did not improve endurance performance during repeated bouts of high-intensity exercise, despite the significant initial increase in absolute peak force and anti-inflammatory effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 86, August 2014, Pages 10–15
نویسندگان
, , , , , , , , , ,