A new and efficient method for the synthesis of Ulipristal acetate

• We have succeeded in finding another convenient and efficient synthetic route for the synthesis of Ulipristal acetate with a good yield.
• The yield of 11β-substituted isomer was greatly improved.
• The 17β-carbonitrile compound was obtained with high purity after the reaction.
• The yield of once Grignard addition dione was greatly improved.
• These synthetic procedures are much suitable for industrial process.

In this study, we describe another new and efficient route for preparing Ulipristal acetate. The 1,4-addition compound 5 was greatly improved after the starting material ketone 1 was underwent epoxidation, cyanation, hydroxyl group protection and Grignard addition. The synthetic procedure is only 6 steps and the total yield is about 27.4%, which is much suitable for industrial process.

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