کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2029320 1070550 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium
چکیده انگلیسی

Six new steroidal saponins, pandarosides K–M (1–3) and their methyl esters (4–6), were isolated as minor components, after a careful chemical reinvestigation of the Caribbean sponge Pandaros acanthifolium. Their structures were established on the basis of spectroscopic analyses and comparison with the data obtained from previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides were tested on three human tumour cell lines, and their haemolytic and liposome permeabilizing activity were assessed. Two pandarosides exhibited moderate to strong cytotoxic effect, while three acanthifoliosides showed strong haemolytic activity.

Six new steroidal saponins, pandarosides K–M (1–3) and their methyl esters (4–6), were isolated from the Caribbean sponge Pandaros acanthifolium as minor components, and together with previously reported pandarosides and acanthifoliosides were tested against four parasitic protozoa, on three human tumour cell lines, and their haemolytic and liposome permeabilizing activity were assessed. Pandarosides showed the best antiprotozoal and cytotoxic profiles without haemolytic effect, while acanthifoliosides exhibited a strong haemolytic action.Figure optionsDownload as PowerPoint slideHighlights
► Full chemical characterization of six new pandaroside saponins.
► Biological screening for their in vitro antitumour, antiprotozoal and haemolytic activity.
► All mentioned biological assays on pandaroside analogues, as well as acanthifolioside saponins.
► Valuable SARs for this class of compounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 76, Issue 12, November 2011, Pages 1389–1396
نویسندگان
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