New anti-inflammatory 4-methylated steroids from the Formosan soft coral Nephthea chabroli

Eight new 4-methylated steroids, nebrosteroids A–H (1–8) were isolated from the acetone solubles of the Formosan soft coral Nephthea chabroli. The structures were elucidated by extensive NMR spectroscopic analysis and their anti-inflammatory activity was measured in vitro.