کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2032016 1071645 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in desmin expression in patients with cardiac diastolic dysfunction and preserved or reduced ejection fraction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Changes in desmin expression in patients with cardiac diastolic dysfunction and preserved or reduced ejection fraction
چکیده انگلیسی

PurposeDesmin regulates function of mitochondria, T-tubular system and cytosolic Ca2+ transients. We investigated whether desmin remodeling correlates with diastolic dysfunction and whether progressive desmin abnormalities are accompanied by increasing diastolic dysfunction stages.Patients and methodsEighty five patients with idiopathic dilated cardiomyopathy and suspected myocarditis without confirmed cardiac tissue inflammation in histopathology assays were included and divided into groups: with preserved EF and reduced EF. After echocardiographic analysis of diastolic dysfunction we identified 2 preserved EF subgroups (normal diastolic function (NDF) and impaired relaxation (IR)) and 3 reduced EF subgroups (NDF, IR, and pseudonormalization). Patients with preserved EF and NDF formed the control group. Tissue desmin staining revealed 4 types of desmin expression: I – normal, with regular pattern of cross-section, IIA – increased with regular pattern, IIB – increased, with irregular pattern and presence of aggregates, III – decreased/lack desmin.ResultsDesmin I was observed only in patients with NDF n = 8 (100%) in preserved EF and reduced EF, desmin IIA in NDF n = 8 (33%) in preserved EF and n = 5 (33%) in reduced EF and IR n = 16 (66%) in preserved EF and n = 10 (66%) in reduced EF. Desmin IIB and III were observed in patients with reduced EF and diastolic dysfunction: IR and pseudonormalization n = 9 (39%) and n = 2 (29%); n = 14 (61%) and n = 5 (71%), respectively. Desmin was found to be an independent predictor of diastolic function parameters β = −0.63, R2 = 0.52 for E′; β = 0.54, R2 = 0.42 for E/E′.ConclusionsIncreasing desmin abnormalities were correlated with diastolic dysfunction progression. Desmin expression represents a novel factor contributing or paralleling the development of diastolic dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Medical Sciences - Volume 60, Issue 1, March 2015, Pages 148–155
نویسندگان
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