کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2035177 1072143 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury
ترجمه فارسی عنوان
بازخورد اسپیندل عضلانی دستورالعمل احیاء حرکتی و تنظیم مجدد مدار پس از آسیب نخاعی است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی


• Muscle spindle afferents influence specific aspects of locomotor control
• Muscle spindle feedback directs locomotor recovery after spinal cord injury
• Descending detour circuit formation is facilitated by muscle spindle feedback

SummarySpinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional muscle spindle feedback to determine the role of this sensory channel in gait control and locomotor recovery after spinal cord injury. High-resolution kinematic analysis of intact mutant mice revealed proficient execution in basic locomotor tasks but poor performance in a precision task. After injury, wild-type mice spontaneously recovered basic locomotor function, whereas mice with deficient muscle spindle feedback failed to regain control over the hindlimb on the lesioned side. Virus-mediated tracing demonstrated that mutant mice exhibit defective rearrangements of descending circuits projecting to deprived spinal segments during recovery. Our findings reveal an essential role for muscle spindle feedback in directing basic locomotor recovery and facilitating circuit reorganization after spinal cord injury.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 159, Issue 7, 18 December 2014, Pages 1626–1639
نویسندگان
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