کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2035589 1072199 2012 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome
چکیده انگلیسی

SummaryPathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.

Graphical AbstractFigure optionsDownload high-quality image (310 K)Download as PowerPoint slideHighlights
► The enteric virome expands during pathogenic, but not nonpathogenic, SIV infection
► Pathogenic SIV-infected rhesus monkeys shed multiple enteric viruses
► Viruses are associated with intestinal pathology during SIV infection
► Metagenomic analysis of the enteric virome is important to study AIDS pathogenesis

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 151, Issue 2, 12 October 2012, Pages 253–266
نویسندگان
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