کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2036051 1072242 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans
چکیده انگلیسی

SummaryInduced expression of the Flock House virus in the soma of C. elegans results in the RNAi-dependent production of virus-derived, small-interfering RNAs (viRNAs), which in turn silence the viral genome. We show here that the viRNA-mediated viral silencing effect is transmitted in a non-Mendelian manner to many ensuing generations. We show that the viral silencing agents, viRNAs, are transgenerationally transmitted in a template-independent manner and work in trans to silence viral genomes present in animals that are deficient in producing their own viRNAs. These results provide evidence for the transgenerational inheritance of an acquired trait, induced by the exposure of animals to a specific, biologically relevant physiological challenge. The ability to inherit such extragenic information may provide adaptive benefits to an animal.

Graphical AbstractFigure optionsDownload high-quality image (209 K)Download as PowerPoint slideHighlights
► Viral replication triggers an RNAi-dependent viral silencing response in C. elegans
► The acquired silencing response is transgenerationally transmitted
► Transgenerational transmittance is non-Mendelian and involves small antiviral RNAs
► An RdRP is required for long-term maintenance of the silencing response

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 147, Issue 6, 9 December 2011, Pages 1248–1256
نویسندگان
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