کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2036051 | 1072242 | 2011 | 9 صفحه PDF | دانلود رایگان |

SummaryInduced expression of the Flock House virus in the soma of C. elegans results in the RNAi-dependent production of virus-derived, small-interfering RNAs (viRNAs), which in turn silence the viral genome. We show here that the viRNA-mediated viral silencing effect is transmitted in a non-Mendelian manner to many ensuing generations. We show that the viral silencing agents, viRNAs, are transgenerationally transmitted in a template-independent manner and work in trans to silence viral genomes present in animals that are deficient in producing their own viRNAs. These results provide evidence for the transgenerational inheritance of an acquired trait, induced by the exposure of animals to a specific, biologically relevant physiological challenge. The ability to inherit such extragenic information may provide adaptive benefits to an animal.
Graphical AbstractFigure optionsDownload high-quality image (209 K)Download as PowerPoint slideHighlights
► Viral replication triggers an RNAi-dependent viral silencing response in C. elegans
► The acquired silencing response is transgenerationally transmitted
► Transgenerational transmittance is non-Mendelian and involves small antiviral RNAs
► An RdRP is required for long-term maintenance of the silencing response
Journal: - Volume 147, Issue 6, 9 December 2011, Pages 1248–1256