Rescue of ΔF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway

► Mechanisms associated with ER stress activate unconventional protein secretion ► The GRASP-dependent pathway traffics core-glycosylated CFTR to the cell surface ► GRASP specifically associates with CFTR by a PDZ-based mechanism ► GRASP rescues the defects of ΔF508-CFTR in HEK293 cells and mice