کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2036552 | 1072270 | 2010 | 13 صفحه PDF | دانلود رایگان |

SummarySkeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and β-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis.
Graphical AbstractFigure optionsDownload high-quality image (266 K)Download as PowerPoint slideHighlights
► The transcription factor Nfix acts as a switch in skeletal muscle development
► Nfix activates fetal specific genes and represses embryonic genes
► Premature expression of Nfix activates fetal and suppresses embryonic genes
► Ablation of Nfix prevents fetal and maintains embryonic gene expression
Journal: - Volume 140, Issue 4, 19 February 2010, Pages 554–566