کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2036618 1072273 2009 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
چکیده انگلیسی

SummaryThe gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 139, Issue 3, 30 October 2009, Pages 485–498
نویسندگان
, , , , , , , , , , , , , , ,