کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2036652 1072274 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size
چکیده انگلیسی

SummaryCytokinesis is accomplished by constriction of a cortical contractile ring. We show that during the early embryonic divisions in C. elegans, ring constriction occurs in two phases—an initial phase at a constant rate followed by a second phase during which the constriction rate decreases in proportion to ring perimeter. Cytokinesis completes in the same amount of time, despite the reduction in cell size during successive divisions, due to a strict proportionality between initial ring size and the constant constriction rate. During closure, the myosin motor in the ring decreases in proportion to perimeter without turning over. We propose a “contractile unit” model to explain how the ring retains a structural memory of its initial size as it disassembles. The scalability of constriction may facilitate coordination of mitotic events and cytokinesis when cell size, and hence the distance traversed by the ring, varies during embryogenesis and in other contexts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 137, Issue 5, 29 May 2009, Pages 926–937
نویسندگان
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