کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2036675 1072275 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Patterning Axon Targeting of Olfactory Receptor Neurons by Coupled Hedgehog Signaling at Two Distinct Steps
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Patterning Axon Targeting of Olfactory Receptor Neurons by Coupled Hedgehog Signaling at Two Distinct Steps
چکیده انگلیسی

SummaryWe present evidence for a coupled two-step action of Hedgehog signaling in patterning axon targeting of Drosophila olfactory receptor neurons (ORNs). In the first step, differential Hedgehog pathway activity in peripheral sensory organ precursors creates ORN populations with different levels of the Patched receptor. Different Patched levels in ORNs then determine axonal responsiveness to target-derived Hedgehog in the brain: only ORN axons that do not express high levels of Patched are responsive to and require a second step of Hedgehog signaling for target selection. Hedgehog signaling in the imaginal sensory organ precursors thus confers differential ORN responsiveness to Hedgehog-mediated axon targeting in the brain. This mechanism contributes to the spatial coordination of ORN cell bodies in the periphery and their glomerular targets in the brain. Such coupled two-step signaling may be more generally used to coordinate other spatially and temporally segregated developmental events.

Graphical AbstractFigure optionsDownload high-quality image (108 K)Download as PowerPoint slideHighlights
► Peripheral hedgehog signaling creates olfactory neurons with different Patched levels
► Olfactory axons reuse Hedgehog, produced by the central brain, for target selection
► Only axons with low levels of Patched are responsive to the second round of signaling
► This mechanism coordinates peripheral cell-body positions with central axon targets

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 142, Issue 6, 17 September 2010, Pages 954–966
نویسندگان
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