Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

► ErbB ligands EGF and HRG induce transient versus sustained cytoplasmic ERK activity ► Nuclear ERK activity and c-fos mRNA expression are transient for both ligands ► HRG induces increased expression of c-fos, ERK phosphatases, and a c-fos repressor ► Signaling-transcription cascades robustly discriminate different ERK dynamics