کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2036825 1072284 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
چکیده انگلیسی

SummaryBehavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 139, Issue 2, 16 October 2009, Pages 416–427
نویسندگان
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