کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2036928 | 1072290 | 2008 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations](/preview/png/2036928.png)
SummaryChromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and is found in Burkitt's lymphomas in humans and plasmacytomas in mice. DNA breaks in IgH leading to c-myc/IgH translocations are created by activation-induced cytidine deaminase (AID) during antibody class switch recombination or somatic hypermutation. However, the source of DNA breaks at c-myc is not known. Here, we provide evidence for the c-myc promoter region being required in targeting AID-mediated DNA damage to produce DSBs in c-myc that lead to c-myc/IgH translocations in primary B lymphocytes. Thus, in addition to producing somatic mutations and DNA breaks in antibody genes, AID is also responsible for the DNA lesions in oncogenes that are required for their translocation.
Journal: - Volume 135, Issue 6, 12 December 2008, Pages 1028–1038