کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2037072 1072298 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A General O-Glycosylation System Important to the Physiology of a Major Human Intestinal Symbiont
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
A General O-Glycosylation System Important to the Physiology of a Major Human Intestinal Symbiont
چکیده انگلیسی

SummaryThe Bacteroides are a numerically dominant genus of the human intestinal microbiota. These organisms harbor a rare bacterial pathway for incorporation of exogenous fucose into capsular polysaccharides and glycoproteins. The infrequency of glycoprotein synthesis by bacteria prompted a more detailed analysis of this process. Here, we demonstrate that Bacteroides fragilis has a general O-glycosylation system. The proteins targeted for glycosylation include those predicted to be involved in protein folding, protein-protein interactions, peptide degradation as well as surface lipoproteins. Protein glycosylation is central to the physiology of B. fragilis and is necessary for the organism to competitively colonize the mammalian intestine. We provide evidence that general O-glycosylation systems are conserved among intestinal Bacteroides species and likely contribute to the predominance of Bacteroides in the human intestine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 137, Issue 2, 17 April 2009, Pages 321–331
نویسندگان
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