کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2037090 1072299 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection
چکیده انگلیسی

SummaryGranulomas, organized aggregates of immune cells, form in response to persistent stimuli and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host-protective structures formed to contain infection. However, work in zebrafish infected with Mycobacterium marinum suggests that granulomas contribute to early bacterial growth. Here we use quantitative intravital microscopy to reveal distinct steps of granuloma formation and assess their consequence for infection. Intracellular mycobacteria use the ESX-1/RD1 virulence locus to induce recruitment of new macrophages to, and their rapid movement within, nascent granulomas. This motility enables multiple arriving macrophages to efficiently find and phagocytose infected macrophages undergoing apoptosis, leading to rapid, iterative expansion of infected macrophages and thereby bacterial numbers. The primary granuloma then seeds secondary granulomas via egress of infected macrophages. Our direct observations provide insight into how pathogenic mycobacteria exploit the granuloma during the innate immune phase for local expansion and systemic dissemination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 136, Issue 1, 9 January 2009, Pages 37–49
نویسندگان
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