کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2037353 1072313 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1
چکیده انگلیسی

SummaryDuring nervous system development, spinal commissural axons project toward and across the ventral midline. They are guided in part by netrin-1, made by midline cells, which attracts the axons by activating the netrin receptor DCC. However, previous studies suggest that additional receptor components are required. Here, we report that the Down's syndrome Cell Adhesion Molecule (DSCAM), a candidate gene implicated in the mental retardation phenotype of Down's syndrome, is expressed on spinal commissural axons, binds netrin-1, and is necessary for commissural axons to grow toward and across the midline. DSCAM and DCC can each mediate a turning response of these neurons to netrin-1. Similarly, Xenopus spinal neurons exogenously expressing DSCAM can be attracted by netrin-1 independently of DCC. These results show that DSCAM is a receptor that can mediate turning responses to netrin-1 and support a key role for netrin/DSCAM signaling in commissural axon guidance in vertebrates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 133, Issue 7, 27 June 2008, Pages 1241–1254
نویسندگان
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