کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2037432 1072317 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex-Specific Control and Tuning of the Pattern Generator for Courtship Song in Drosophila
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Sex-Specific Control and Tuning of the Pattern Generator for Courtship Song in Drosophila
چکیده انگلیسی

SummaryThe differentially spliced transcription factors encoded by the fruitless (fru) gene are key determinants of sexual behavior in Drosophila. They are expressed in a minority of neurons with limited dimorphisms and regulate neural processes that remain largely unknown. Here, we use light-activated ion channels to stimulate fru-expressing neurons in the thoracic-abdominal ganglia, enabling direct functional comparisons of homologous circuitry between sexes. Optical stimulation of males or females initiates the unilateral wing vibrations that normally generate the male courtship song. The pattern-generating circuit operates differently in the two sexes, producing wing movement and sound in both but authentic songs only in males and in females expressing male fru product. A song-like motor program is thus present in females but lies dormant because the neural commands required for song initiation are absent. Supplying such commands artificially reveals fru-specific differences in the internal dynamics of the song generator and sets the stage for exploring their physiological basis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 133, Issue 2, 18 April 2008, Pages 354–363
نویسندگان
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