کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2037449 | 1072321 | 2008 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B](/preview/png/2037449.png)
SummaryGlycoprotein B (gB) is one of the essential components for infection by herpes simplex virus-1 (HSV-1). Although several cellular receptors that associate with glycoprotein D (gD), such as herpes virus entry mediator (HVEM) and Nectin-1, have been identified, specific molecules that mediate HSV-1 infection by associating with gB have not been elucidated. Here, we found that paired immunoglobulin-like type 2 receptor (PILR) α associates with gB, and cells transduced with PILRα become susceptible to HSV-1 infection. Furthermore, HSV-1 infection of human primary cells expressing both HVEM and PILRα was blocked by either anti-PILRα or anti-HVEM antibody. Our results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRα plays an important role in HSV-1 infection as a coreceptor that associates with gB. These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection.
Journal: - Volume 132, Issue 6, 21 March 2008, Pages 935–944