کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2037524 1072324 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
چکیده انگلیسی

SummaryNovel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell stem/progenitor cells. However, whether or not adult β cell progenitors exist is one of the most controversial issues in today's diabetes research. Guided by the expression of Neurogenin 3 (Ngn3), the earliest islet cell-specific transcription factor in embryonic development, we show that β cell progenitors can be activated in injured adult mouse pancreas and are located in the ductal lining. Differentiation of the adult progenitors is Ngn3 dependent and gives rise to all islet cell types, including glucose responsive β cells that subsequently proliferate, both in situ and when cultured in embryonic pancreas explants. Multipotent progenitor cells thus exist in the pancreas of adult mice and can be activated cell autonomously to increase the functional β cell mass by differentiation and proliferation rather than by self-duplication of pre-existing β cells only.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 132, Issue 2, 25 January 2008, Pages 197–207
نویسندگان
, , , , , , , , , , , , , ,