کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2037917 1072342 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
چکیده انگلیسی

SummaryBesides their role in desensitization, β-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, β-arrestin 2, and protein phosphatase 2A. When administered to β-arrestin 2 knockout mice, lithium fails to affect Akt/GSK3 signaling and induce behavioral changes associated with GSK3 inhibition as it does in normal animals. These results point toward a pharmacological approach to modulating GPCR function that affects the formation of β-arrestin-mediated signaling complexes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 132, Issue 1, 11 January 2008, Pages 125–136
نویسندگان
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