کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2038021 1072346 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient
چکیده انگلیسی

SummaryThe different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (mok) mutants, in which the motor protein Dynactin-1 is disrupted, interkinetic nuclei migrate more rapidly and deeply to the basal side and more slowly to the apical side. We found that Notch signaling is predominantly activated on the apical side in both mutants and wild-type. Mutant progenitors are, thus, less exposed to Notch and exit the cell cycle prematurely. This leads to an overproduction of early-born retinal ganglion cells (RGCs) at the expense of later-born interneurons and glia. Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 134, Issue 6, 19 September 2008, Pages 1055–1065
نویسندگان
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