کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2038094 1072349 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons
چکیده انگلیسی

SummaryThe polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain. We show here that the serine/threonine kinase LKB1, previously implicated in the establishment of epithelial polarity and control of cell growth, is required for axon specification during neuronal polarization in the mammalian cerebral cortex. LKB1 polarizing activity requires its association with the pseudokinase Stradα and phosphorylation by kinases such as PKA and p90RSK, which transduce neurite outgrowth-promoting cues. Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex. SAD kinases, in turn, phosphorylate effectors such as microtubule-associated proteins that implement polarization. Thus, we provide evidence in vivo and in vitro for a multikinase pathway that links extracellular signals to the intracellular machinery required for axon specification.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 129, Issue 3, 4 May 2007, Pages 549–563
نویسندگان
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