کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2038138 1072351 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin
چکیده انگلیسی

SummaryThe effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find that human breast carcinomas instigate the growth of otherwise-indolent tumor cells, micrometastases, and human tumor surgical specimens located at distant anatomical sites. This systemic instigation is accompanied by incorporation of bone-marrow cells (BMCs) into the stroma of the distant, once-indolent tumors. We find that BMCs of hosts bearing instigating tumors are functionally activated prior to their mobilization; hence, when coinjected with indolent cells, these activated BMCs mimic the systemic effects imparted by instigating tumors. Secretion of osteopontin by instigating tumors is necessary for BMC activation and the subsequent outgrowth of the distant otherwise-indolent tumors. These results reveal that outgrowth of indolent tumors can be governed on a systemic level by endocrine factors released by certain instigating tumors, and hold important experimental and therapeutic implications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 133, Issue 6, 13 June 2008, Pages 994–1005
نویسندگان
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