کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2038320 1072361 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nodal Flow and the Generation of Left-Right Asymmetry
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Nodal Flow and the Generation of Left-Right Asymmetry
چکیده انگلیسی

The establishment of left-right asymmetry in mammals is a good example of how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node, called nodal flow, is the central process in symmetry breaking on the left-right axis. Nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node. These cilia are built by transport via the KIF3 motor complex. How nodal flow is interpreted to create left-right asymmetry has been a matter of debate. Recent evidence suggests that the leftward movement of membrane-sheathed particles, called nodal vesicular parcels (NVPs), may result in the activation of the noncanonical Hedgehog signaling pathway, an asymmetric elevation in intracellular Ca2+ and changes in gene expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 125, Issue 1, 7 April 2006, Pages 33–45
نویسندگان
, , , ,