کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2039844 | 1073085 | 2016 | 12 صفحه PDF | دانلود رایگان |
• bHLH proteins Daughterless and Tcf4 are present in postmitotic neurons
• bHLH proteins Daughterless and Tcf4 restrict branching in postmitotic neurons
• Daughterless and Tcf4 repress Neurexin expression in postmitotic neurons
• Daughterless homodimers restrict branching in postmitotic neurons
SummaryProneural proteins of the class I/II basic-helix-loop-helix (bHLH) family are highly conserved transcription factors. Class I bHLH proteins are expressed in a broad number of tissues during development, whereas class II bHLH protein expression is more tissue restricted. Our understanding of the function of class I/II bHLH transcription factors in both invertebrate and vertebrate neurobiology is largely focused on their function as regulators of neurogenesis. Here, we show that the class I bHLH proteins Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation. Our data indicate that Daughterless performs this function in part by restricting the expression of the cell adhesion molecule Neurexin. This suggests a role for these proteins outside of their established roles in neurogenesis.
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Journal: - Volume 15, Issue 2, 12 April 2016, Pages 386–397