کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040022 1073094 2015 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis
ترجمه فارسی عنوان
کنترل همراه سلول های بنیادی سلول های بنیادی تخمدان، میکروسکوپ و هوموتوزیس
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• “Companion” hemocytes associate with the female larval gonad
• Hemocytes produce functional ECM in the germline stem cell (GSC) niche
• Loss of hemocyte-derived CollIV leads to abnormal stem cell niche with excess GSCs
• Hemocyte-derived CollIV controls the extent of BMP signaling and niche homeostasis

SummaryThe extracellular matrix plays an essential role for stem cell differentiation and niche homeostasis. Yet, the origin and mechanism of assembly of the stem cell niche microenvironment remain poorly characterized. Here, we uncover an association between the niche and blood cells, leading to the formation of the Drosophila ovarian germline stem cell niche basement membrane. We identify a distinct pool of plasmatocytes tightly associated with the developing ovaries from larval stages onward. Expressing tagged collagen IV tissue specifically, we show that the germline stem cell niche basement membrane is produced by these “companion plasmatocytes” in the larval gonad and persists throughout adulthood, including the reproductive period. Eliminating companion plasmatocytes or specifically blocking their collagen IV expression during larval stages results in abnormal adult niches with excess stem cells, a phenotype due to aberrant BMP signaling. Thus, local interactions between the niche and blood cells during gonad development are essential for adult germline stem cell niche microenvironment assembly and homeostasis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 3, 20 October 2015, Pages 546–560
نویسندگان
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