کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047431 1073975 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
چکیده انگلیسی
The mechanisms involved in bidirectional transport along microtubules remain largely unknown. We explored the collective action of kinesin-2 and dynein motors during transport of melanosomes in Xenopus laevis melanophores. These motors are attached to organelles through accessory proteins establishing a complex molecular linker. We determined both the stiffness of this linker and the organelles speed and observed that these parameters depended on the organelle size and cargo direction. Our results suggest that melanosome transport is driven by two dissimilar teams: whereas dynein motors compete with kinesin-2 affecting the properties of plus-end directed organelles, kinesin-2 does not seem to play a similar role during minus-end transport.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 19, Part B, 14 September 2015, Pages 2763-2768
نویسندگان
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