کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2047592 | 1074004 | 2014 | 8 صفحه PDF | دانلود رایگان |

• Tudor-SN binds and co-localizes with AGTR1-3′UTR (3′-untranslated region of angiotensin II receptor, type 1 mRNA) in SG.
• Tudor-SN plays an important role in the assembly of AGTR1-3′UTR granules.
• Tudor-SN knockdown decreases the recovery kinetics of AGTR1-3′UTR granules.
• Our results suggest an additional biological role of Tudor-SN in RNA metabolism during stress.
Human Tudor staphylococcal nuclease (Tudor-SN) interacts with the G3BP protein and is recruited into stress granules (SGs), the main type of discrete RNA-containing cytoplasmic foci structure that is formed under stress conditions. Here, we further demonstrate that Tudor-SN binds and co-localizes with AGTR1-3′UTR (3′-untranslated region of angiotensin II receptor, type 1 mRNA) into SG. Tudor-SN plays an important role in the assembly of AGTR1-3′UTR granules. Moreover, endogenous Tudor-SN knockdown can decrease the recovery kinetics of AGTR1-3′UTR granules. Collectively, our data indicate that Tudor-SN modulates the kinetics of AGTR1-3′UTR granule formation, which provides an additional biological role of Tudor-SN in RNA metabolism during stress.
Journal: FEBS Letters - Volume 588, Issue 13, 13 June 2014, Pages 2154–2161